xov xwm

Raws li lub cev pob txha aza-BODIPY, NIR1001 suav nrog cov pab pawg electron-dawb (piv txwv li, 4-N, N-diphenylaminophenyl) ntawm 2,6-txoj hauj lwm, tsim ib qho symmetric D-π-D structure1. Qhov kev tsim no nqaim qhov sib txawv ntawm HOMO-LUMO, hloov lub siab nqus siab tshaj 1000 nm thiab txhim kho cov nqi hloov pauv hloov pauv (ICT). Hauv THF, NIR1001 nthuav tawm qhov siab tshaj plaws ob-photon absorption (TPA) ntu ntu ntawm 37 GM, kev txhim kho ob npaug ntawm cov khoom siv BODIPY derivatives. Nws zoo siab-lub xeev lub neej ntawm 1.2 ps ua rau muaj kev hloov pauv tsis zoo, ua rau nws tsim nyog rau kev kho mob photodynamic (PDT).

Kev suav DFT qhia tau hais tias tus nqi hloov pauv ntawm NIR1001 tshwm sim los ntawm π-electron delocalization ntawm tus neeg pub dawb thiab tus neeg txais cov moieties. Kev hloov kho Methoxy ntxiv txhim kho NIR nqus nyob rau hauv lub qhov rais phototherapeutic (650-900 nm), txhim kho rhiab heev1. Piv rau Fudan University's AF dyes, NIR1001 tswj qhov hnyav molecular me me (<500 Da) nrog 40% siab dua photostability. Kev hloov kho carboxylation txhim kho cov dej solubility (cLogD = 1.2), txo qis adsorption tsis tshwj xeeb hauv cov kab mob lom.

3. Biomedical Applications
Hauv bioimaging, hCG-conjugated sojntsuam hCG-NIR1001 ua tiav cov duab daws teeb meem ntawm zes qe menyuam follicles thiab micro-metastases hauv qab 808 nm excitation. Nrog rau qhov tob tob ntawm 3 cm hauv NIR-II, nws ua haujlwm zoo dua NIR-I kev sojntsuam los ntawm peb npaug, thaum txo cov fluorescence tom qab los ntawm 60%. Nyob rau hauv tus qauv nas raum raug mob, NIR1001 qhia 85% raum tshwj xeeb uptake, kuaj pom kev puas tsuaj rau lub sij hawm sai dua li macromolecular tswj.
Rau PDT, NIR1001 generates reactive oxygen hom (ROS) ntawm 0.85 μmol / J nyob rau hauv 1064 nm laser irradiation, zoo inducing qog cell apoptosis. Liposome-encapsulated NIR1001 nanoparticles (NPs) khaws 7.2 npaug ntau dua hauv cov qog ntau dua li cov xim dawb, txo qis cov teebmeem ntawm lub hom phiaj.
4. Muaj thiab ib puag ncig saib xyuas
Hauv cov ntawv thov kev lag luam, NIR1001 tau koom ua ke rau hauv Juhang Technology's SupNIR-1000 analyzer rau kev faib cov txiv hmab txiv ntoo, kev ntsuam xyuas nqaij zoo, thiab kev ua luam yeeb. Ua haujlwm nyob rau hauv 900-1700 nm ntau, nws ib txhij ntsuas cov ntsiab lus qab zib, noo noo, thiab tshuaj tua kab residues hauv 30 vib nas this nrog ± (50ppm + 5% kev nyeem ntawv) raug. Hauv automotive CO2 sensors (ACDS-1001), NIR1001 ua rau kev saib xyuas lub sijhawm tiag tiag nrog T90≤25s lub sijhawm teb thiab 15-xyoo lifespan.
Rau kev tshawb nrhiav ib puag ncig, NIR1001-functionalized probes ntes cov hlau hnyav hauv dej. Nyob rau hauv pH 6.5-8.0, fluorescence intensity linearly correlates nrog Hg²⁺ concentration (0.1-10 μM) nrog rau kev kuaj pom txwv ntawm 0.05 μM, outperforming colorimetric txoj kev los ntawm ob qhov kev txiav txim ntawm magnitude.
5. Technology Innovation thiab Commercialization
Qingdao Topwell cov ntaub ntawvUa haujlwm txuas ntxiv los tsim NIR1001 ntawm 99.5% purity, nrog 50 kg / batch muaj peev xwm. Siv microchannel reactors, Knoevenagel condensation lub sij hawm raug txo los ntawm 12 teev mus rau 30 feeb, txiav lub zog noj los ntawm 60%. ISO 13485-certified NIR1001 series dominates lub lag luam biomedical.